在三种哺乳动物淋巴细胞中，环磷酰胺在无外源性代谢活化的情况下体外诱导的姐妹染色单体交换。
Sister-chromatid exchanges induced in vitro by cyclophosphamide without exogenous metabolic activation in lymphocytes from three mammalian species.
作者信息
Waalkens D H, Joosten H F, Taalman R D, Scheres J M, Yih T D, Hoekstra A
出版信息
Toxicol Lett. 1981 Jan;7(3):229-32. doi: 10.1016/0378-4274(81)90073-4.
PMID:7222098
Abstract
The induction of sister-chromatid exchanges (SCEs) by cyclophosphamide (CP) in human, rat and rabbit lymphocytes was studied in vitro without exogenous metabolic activation. In contrast with published reports, CP induced SCEs in lymphocytes from all three species, indicating that cultured lymphocytes possess the metabolic capacity to convert this indirect-acting mutagen.
摘要
在无外源性代谢活化的情况下，对环磷酰胺（CP）在人、大鼠和兔淋巴细胞中诱导姐妹染色单体交换（SCEs）的情况进行了体外研究。与已发表的报告不同，CP在所有这三个物种的淋巴细胞中均诱导了SCEs，这表明培养的淋巴细胞具有将这种间接作用诱变剂进行转化的代谢能力。
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