热对人血浆中邻苯二甲酸二（2-乙基己基）酯转化为邻苯二甲酸单（2-乙基己基）酯的影响。

Effect of heat on the conversion of di-2-ethylhexyl phthalate to mono-2-ethylhexyl phthalate in human plasma.

作者信息

Peck C C, Odom D G, Albro P W, Jess D A, Barrett B B

出版信息

Transfusion. 1981 Mar-Apr;21(2):163-6. doi: 10.1046/j.1537-2995.1981.21281178151.x.

DOI:10.1046/j.1537-2995.1981.21281178151.x

Abstract

Plasma di-2-ethylhexyl phthalate (DEHP), which accumulates during blood storage in plastic bags, gives rise to plasma mono-2-ethylhexyl phthalate (MEHP). This also in plasma samples awaiting analysis, which are no longer stored in plastic bags. Heating plasma samples at 60 C for 25 to 30 minutes in a water bath effectively halts conversion of DEHP to MEHP during subsequent room temperature storage for at least 100 hours. This result is consistent with the view that MEHP accumulation in plasma is due to enzymatic hydrolysis of DEHP by esterase (s) which can be heat-inactivated.

摘要

血浆中的邻苯二甲酸二（2-乙基己基）酯（DEHP）在塑料袋储存血液期间会蓄积，并生成血浆中的邻苯二甲酸单（2-乙基己基）酯（MEHP）。在等待分析的血浆样本中也是如此，这些样本不再储存在塑料袋中。将血浆样本在水浴中于60℃加热25至30分钟，可有效阻止在随后至少100小时的室温储存期间DEHP向MEHP的转化。这一结果与以下观点一致，即血浆中MEHP的蓄积是由于DEHP被酯酶进行酶促水解所致，而酯酶可被热灭活。