邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸单（2-乙基己基）酯（MEHP）在全血和红细胞浓缩物中的蓄积。

Di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) accumulation in whole blood and red cell concentrates.

作者信息

Peck C C, Odom D G, Friedman H I, Albro P W, Hass J R, Brady J T, Jess D A

出版信息

Transfusion. 1979 Mar-Apr;19(2):137-46. doi: 10.1046/j.1537-2995.1979.19279160282.x.

DOI:10.1046/j.1537-2995.1979.19279160282.x

Abstract

Plasma DEHP concentrations were measured weekly in whole blood and red cell concentrates (RCC) during 21 days of storage in standard CPD within PL-130 blood bags. In addition, DEHP and MEHP accumulation patterns were investigated in blood stored for 42 days in modified CPD with adenine within PL-146 and BB-69 storage containers. Total per-unit plasma DEHP of RCC units was 49 to 71 per cent of the total in plasma of whole blood units (PL-130). From 28 to 42 days, mean DEHP levels were 12 to 19 per cent higher in whole blood stored in PL-146 than in BB-69. Although MEHP was not found in any blood bag plastic, MEHP accumulated in plasma during whole blood storage. MEHP concentrations were 2.8 to 3.8 times higher in plasma stored in BB-69 than in PL-146. It is postulated that MEHP arises from hydrolysis of DEHP by plasma lipase, even in frozen plasma sample, and that the rate of this reaction is influenced by blood bag plastic surface characteristics.

摘要

在PL - 130血袋中，于标准CPD中储存21天期间，每周测定全血和红细胞浓缩液（RCC）中的血浆邻苯二甲酸二（2 - 乙基己基）酯（DEHP）浓度。此外，还研究了在PL - 146和BB - 69储存容器中，于含腺嘌呤的改良CPD中储存42天的血液中DEHP和单（2 - 乙基己基）邻苯二甲酸酯（MEHP）的积累模式。RCC单位的每单位血浆DEHP总量为全血单位（PL - 130）血浆总量的49%至71%。在28至42天期间，储存在PL - 146中的全血中的平均DEHP水平比储存在BB - 69中的全血高12%至19%。尽管在任何血袋塑料中均未发现MEHP，但在全血储存期间MEHP在血浆中积累。储存在BB - 69中的血浆中的MEHP浓度比储存在PL - 146中的血浆高2.8至3.8倍。据推测，即使在冷冻血浆样本中，MEHP也是由血浆脂肪酶对DEHP的水解产生的，并且该反应的速率受血袋塑料表面特性的影响。