Nilsson E, Lamke L O, Liljedahl S O, Elfström K
Acta Chir Scand. 1980;146(8):619-22.
Patients with colorectal cancer undergoing elective surgery with resection of the tumour and primary anastomosis were randomly allocated into two groups. 29 patients received a total of 60-75 g of albumin postoperatively, 30 patients received no albumin and served as controls. The two groups were comparable with respect to age and sex of the patients and stage of growth of the tumour. The patients who received albumin had a significantly lower preoperative serum albumin concentration. On day 4 after the operation the serum albumin concentrations of the control patients and the patients who received albumin were 20% and 5% lower, respectively, than the preoperative value. Eight patients of the albumin group and 5 of the control group developed postoperative complications. There was no significant difference in the postoperative clinical course between the two groups. Preoperative serum albumin levels did not differ between patients who developed postoperative complications and those who had an uneventful postoperative course whether or not they received albumin postoperatively. The present study does not confirm earlier results indicating that serum albumin alone is of prognostic value for the postoperative course following colorectal surgery. Furthermore, the postoperative course is not improved by addition of albumin postoperatively and hence albumin should be given in this situation only when its specific oncotic effect is required.
接受择期手术切除肿瘤并进行一期吻合的结直肠癌患者被随机分为两组。29例患者术后共接受60 - 75克白蛋白，30例患者未接受白蛋白作为对照。两组在患者的年龄、性别和肿瘤生长阶段方面具有可比性。接受白蛋白的患者术前血清白蛋白浓度显著较低。术后第4天，对照组患者和接受白蛋白的患者血清白蛋白浓度分别比术前值低20%和5%。白蛋白组有8例患者和对照组有5例患者发生术后并发症。两组术后临床过程无显著差异。无论术后是否接受白蛋白，发生术后并发症的患者与术后过程平稳的患者术前血清白蛋白水平无差异。本研究未证实早期结果，即单独血清白蛋白对结直肠手术后的病程具有预后价值。此外，术后补充白蛋白并不能改善术后病程，因此仅在需要其特定的胶体渗透压作用时才应在这种情况下给予白蛋白。
