Storm H, van Hardeveld C, Kassenaar A A
Acta Endocrinol (Copenh). 1981 May;97(1):91-7. doi: 10.1530/acta.0.0970091.
Basal plasma levels for adrenalin (A), noradrenalin (NA), L-triiodothyronine (T3), and L-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4 degrees C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4 degrees C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23 degrees C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.
通过长期植入导管的方式测定大鼠肾上腺素（A）、去甲肾上腺素（NA）、L-三碘甲状腺原氨酸（T3）和L-甲状腺素（T4）的基础血浆水平。本报告所述实验在手术操作3天后开始，此时T3和T4水平已恢复正常。儿茶酚胺的基础水平在术后4小时就已达到。在4℃饲养的大鼠中，血浆中T3/T4比值在3天、7天和14天后显著升高，4℃饲养7天和14天后24小时尿液中的碘化物情况也是如此。在相同的寒冷暴露期间，静脉血中NA血浆浓度增加了6至12倍，而A浓度保持在基础水平。在23℃输注NA时，与配对喂养的对照组相比，7天后血浆中T3/T4比值显著升高，24小时尿液中的碘化物排泄情况也是如此。本文进一步证明了交感神经系统在静息状态下对大鼠T4代谢的作用。
