Stjernberg N, Cajander S, Truedsson H, Uddenfeldt P
Acta Med Scand. 1981;209(3):213-6. doi: 10.1111/j.0954-6820.1981.tb11579.x.
In 22 patients with sarcoidosis, symptoms and signs of muscle involvement were scanty, but muscle biopsy showed epithelioid cell granulomas consistent with sarcoidosis in 11 patients (50%). Serial sectioning of the muscle biopsies increased the diagnostic yield. The incidence of muscle involvement was highest among patients with both acute sarcoidosis and erythema nodosum. Involvement of other organs was common in patients with muscle sarcoidosis. In two patients with negative scalene node biopsy and negative bronchial and transbronchial biopsies, muscle biopsy showed histological evidence of sarcoidosis. Muscle involvement is common in patients with sarcoidosis, but in many cases there are few or no symptoms. In patients with both acute sarcoidosis and erythema nodosum, muscle biopsy frequently provides histological evidence of the disease. Good cooperation with the pathologist and serial sectioning of the biopsies are necessary if muscle biopsy is to be used as a routine in the diagnosis of sarcoidosis.
在22例结节病患者中，肌肉受累的症状和体征较少，但肌肉活检显示11例患者（50%）存在与结节病相符的上皮样细胞肉芽肿。对肌肉活检组织进行连续切片可提高诊断率。肌肉受累的发生率在急性结节病合并结节性红斑的患者中最高。肌肉结节病患者常伴有其他器官受累。在2例斜角肌淋巴结活检、支气管活检和经支气管活检均为阴性的患者中，肌肉活检显示有结节病的组织学证据。结节病患者中肌肉受累很常见，但在许多情况下症状很少或没有症状。在急性结节病合并结节性红斑的患者中，肌肉活检常能提供该病的组织学证据。如果要将肌肉活检作为结节病诊断的常规方法，就需要与病理学家密切合作并对活检组织进行连续切片。
