牛血清的组织病理学发病机制。白蛋白诱导的兔关节炎。
Histopathogenesis of bovine serum. Albumin-induced arthritis in the rabbit.
作者信息
Gall E P, Gall E A
出版信息
J Rheumatol. 1980 Jan-Feb;7(1):13-23.
PMID:7354465
Abstract
The sequential histologic changes in a bovine serum albumin (BSA)-induced model of chronic arthritis are described. The deposition of antigen in cartilage appears responsible for the localization of the chronic phase of the lesion, which predominates in synovium contiguous with the meniscus and periarticular ligaments. Theoretically, removal of antigen or immune complexes could play a key role in therapy of immune-mediated arthritis.
摘要
本文描述了牛血清白蛋白（BSA）诱导的慢性关节炎模型中的一系列组织学变化。抗原在软骨中的沉积似乎是病变慢性期定位的原因，该慢性期在与半月板和关节周围韧带相邻的滑膜中占主导。从理论上讲，去除抗原或免疫复合物可能在免疫介导性关节炎的治疗中起关键作用。
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