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他莫昔芬视网膜病变

Tamoxifen retinopathy.

作者信息

McKeown C A, Swartz M, Blom J, Maggiano J M

出版信息

Br J Ophthalmol. 1981 Mar;65(3):177-9. doi: 10.1136/bjo.65.3.177.

DOI:10.1136/bjo.65.3.177
PMID:7225310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1039458/
Abstract

A 63-year-old female on long-term, high-dose tamoxifen treatment for metastatic breast cancer developed bilateral intraretinal refractile opacities, lesions at the level of the retinal pigment epithelium, and cystoid macular oedema.

摘要

一名63岁女性因转移性乳腺癌接受长期大剂量他莫昔芬治疗，出现双侧视网膜内折射性混浊、视网膜色素上皮层病变及黄斑囊样水肿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/89ee5d169b13/brjopthal00183-0046-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/c82bd7da4422/brjopthal00183-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/7a3b6f8c1572/brjopthal00183-0046-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/89ee5d169b13/brjopthal00183-0046-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/c82bd7da4422/brjopthal00183-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/7a3b6f8c1572/brjopthal00183-0046-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/147f/1039458/89ee5d169b13/brjopthal00183-0046-c.jpg

相似文献

1
Tamoxifen retinopathy.他莫昔芬视网膜病变
Br J Ophthalmol. 1981 Mar;65(3):177-9. doi: 10.1136/bjo.65.3.177.
2
Crystalline maculopathy: a rare complication of tamoxifen therapy.晶状体性黄斑病变：他莫昔芬治疗的一种罕见并发症。
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To stop or not? Tamoxifen therapy for secondary prevention of breast cancer in a patient with ocular toxicity.是否停药？他莫昔芬治疗对一名患有眼部毒性的乳腺癌患者进行二级预防。
BMJ Case Rep. 2016 Jan 11;2016:bcr2015213431. doi: 10.1136/bcr-2015-213431.
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Tamoxifen retinopathy: does it really exist?他莫昔芬视网膜病变：它真的存在吗？
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Tamoxifen retinopathy. A case report.他莫昔芬视网膜病变。病例报告。
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The Effects of Adjuvant Tamoxifen Use on Macula Pigment Epithelium Optical Density, Visual Acuity and Retinal Thickness in Patients with Breast Cancer.辅助他莫昔芬使用对乳腺癌患者黄斑色素上皮光学密度、视力和视网膜厚度的影响。
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引用本文的文献

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Optical coherence tomography angiography measurements in tamoxifen associated retinopathy: a systematic review and meta-analysis.他莫昔芬相关性视网膜病变的光学相干断层扫描血管造影测量：一项系统评价和荟萃分析。
BMC Ophthalmol. 2025 Jul 1;25(1):373. doi: 10.1186/s12886-025-03971-7.
2
Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity.利用视觉电生理学监测视网膜和视神经毒性
Biomolecules. 2022 Sep 29;12(10):1390. doi: 10.3390/biom12101390.
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Evaluation of Optic Nerve Head Parameters and Electro-Physiology Among Breast Cancer Patients on Tamoxifen.

本文引用的文献

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Arch Ophthalmol. 1968 Sep;80(3):308-16. doi: 10.1001/archopht.1968.00980050310003.
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Bietti's tapetoretinal degeneration with marginal corneal dystrophy.伴有边缘性角膜营养不良的比埃蒂氏视网膜色素变性
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他莫昔芬治疗的乳腺癌患者视神经乳头参数及电生理评估
Cureus. 2022 Jan 9;14(1):e21042. doi: 10.7759/cureus.21042. eCollection 2022 Jan.
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The response of anti-VEGF therapy and tamoxifen withdrawal of tamoxifen-induced cystoid macular edema in the same patient.同一患者中抗 VEGF 治疗和他莫昔芬停药对他莫昔芬诱导的囊样黄斑水肿的反应。
BMC Ophthalmol. 2021 May 7;21(1):201. doi: 10.1186/s12886-021-01953-z.
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Wide field retinal imaging and the detection of drug associated retinal toxicity.广角视网膜成像与药物相关性视网膜毒性的检测
Int J Retina Vitreous. 2019 Dec 12;5(Suppl 1):26. doi: 10.1186/s40942-019-0172-0. eCollection 2019.
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Tamoxifen Use in a Patient with Idiopathic Macular Telangiectasia Type 2.他莫昔芬在一名特发性2型黄斑毛细血管扩张症患者中的应用
Case Rep Ophthalmol. 2018 Jan 17;9(1):54-60. doi: 10.1159/000485739. eCollection 2018 Jan-Apr.
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Uveoretinal Adverse Effects Presented during Systemic Anticancer Chemotherapy: a 10-Year Single Center Experience.眼葡萄膜不良反应在全身抗癌化疗期间的表现：10 年单中心经验。
J Korean Med Sci. 2018 Feb 12;33(7):e55. doi: 10.3346/jkms.2018.33.e55.
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Crystalline retinopathy association with flupentixol intake.
Int Ophthalmol. 2018 Aug;38(4):1769-1773. doi: 10.1007/s10792-017-0624-1. Epub 2017 Jul 4.
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Drug-induced macular edema.药物性黄斑水肿。
Drugs. 2013 Jun;73(8):789-802. doi: 10.1007/s40265-013-0055-x.
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Breast cancer medications and vision: effects of treatments for early-stage disease.乳腺癌药物与视力：早期疾病治疗的影响。
Curr Eye Res. 2011 Oct;36(10):867-85. doi: 10.3109/02713683.2011.594202. Epub 2011 Aug 5.
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Flecked retina. Appearance secondary to oxalate crystals from methoxyflurane anesthesia.
Arch Ophthalmol. 1975 Jan;93(1):26-31. doi: 10.1001/archopht.1975.01010020030004.
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Tamoxifen retinopathy.他莫昔芬视网膜病变
Cancer Treat Rep. 1978 Mar;62(3):315-20.
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Tamoxifen: a review of its pharmacological properties and therapeutic use in the treatment of breast cancer.他莫昔芬：其药理特性及在乳腺癌治疗中的治疗应用综述。
Drugs. 1978 Jul;16(1):1-24. doi: 10.2165/00003495-197816010-00001.
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Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Jul 17;207(2):91-6. doi: 10.1007/BF00414306.
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Drug-induced phospholipidoses. II. Tissue distribution of the amphiphilic drug chlorphentermine.
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