Nisce L Z, Safai B, Kim J H
Cancer. 1981 Mar 1;47(5):870-6. doi: 10.1002/1097-0142(19810301)47:5<870::aid-cncr2820470510>3.0.co;2-r.
During the past eight years, 137 patients with mycosis fungoides were given total skin electron beam therapy (TSEB) using 2.5 to 4 MeV electrons. A single treatment delivers 400 rads to the entire skin surface, and patients are treated once a week for six to eight consecutive weeks. All have been followed for a median of 18 months (range 6-103 months). Although approximately 80 to 90% of the total population were in the advanced stages of the disease and had been previously treated elsewhere, cutaneous lesions and associated symptoms were effectively controlled. The remission lasted 6 to 103 months (median 19 months) after beginning the therapy for 109 mycosis fungoides patients, who were at risk for 12-103 months (median 24 months). Erythroderma and circulating Sezary cells adversely affected the duration of remission and indicate extracutaneous dissemination. Lymphocyte responsiveness to various mitogens and antigens correlated well with duration of the remission that was obtained from a course of TSEB.
在过去八年中，137例蕈样肉芽肿患者接受了使用2.5至4兆电子伏电子的全身皮肤电子束治疗（TSEB）。单次治疗向整个皮肤表面输送400拉德，患者连续六周或八周每周接受一次治疗。所有患者的中位随访时间为18个月（范围6至103个月）。尽管约80%至90%的患者处于疾病晚期且此前在其他地方接受过治疗，但皮肤病变及相关症状得到了有效控制。109例有缓解风险的蕈样肉芽肿患者在开始治疗后缓解持续6至103个月（中位19个月），缓解期为12至103个月（中位24个月）。红皮病和循环中的Sezary细胞对缓解期有不利影响，提示有皮肤外播散。淋巴细胞对各种有丝分裂原和抗原的反应性与TSEB疗程所获得的缓解期密切相关。
