Effect of herpes simplex virus type 2 and friend erythroleukemia virus infection of IgE antibody responses to Ascaris antigen in mice.

The IgE response to Ascaris antigen, as measured by passive cutaneous anaphylactic reactions, was suppressed in mice infected with either herpes simplex virus type 2 (HSV-2) or Friend leukemia virus (FV). FV was not suppressive unless infection preceded immunization whereas HSV-2 infection was immunosuppressive before or after immunization. However, the suppression by HSV-2 was relatively short-lived.