皮啡肽的氨基酸组成与序列，一种来自索氏叶泡蛙皮肤的新型类阿片肽。

Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei.

作者信息

Montecucchi P C, de Castiglione R, Piani S, Gozzini L, Erspamer V

出版信息

Int J Pept Protein Res. 1981 Mar;17(3):275-83. doi: 10.1111/j.1399-3011.1981.tb01993.x.

DOI:10.1111/j.1399-3011.1981.tb01993.x

Abstract

Dermorphin, a heptapeptide with very potent opiate-like activity, has been isolated from methanol extracts of the skin of the South American frog Phyllomedusa sauvagei. The amino acid sequence of the peptide is: H-Try-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. Dermorphin presents striking differences from the known enkephalins; it offers a surprising example of a peptide from Vertebrata containing a D-amino acid residue in its sequence.

摘要

皮啡肽是一种具有很强类阿片活性的七肽，已从南美蛙（Phyllomedusa sauvagei）皮肤的甲醇提取物中分离出来。该肽的氨基酸序列为：H-酪氨酰-D-丙氨酰-苯丙氨酰-甘氨酰-酪氨酰-脯氨酰-丝氨酰胺。皮啡肽与已知的脑啡肽存在显著差异；它提供了一个脊椎动物来源的肽序列中含有D-氨基酸残基的惊人例子。