复方新诺明敏感性试验：单独及联合纸片琼脂扩散技术的比较
Co-trimoxazole sensitivity testing: comparison of separate and combined disk agar diffusion techniques.
作者信息
Amyes S G, Telfer Brunton W A
出版信息
J Clin Pathol. 1981 Feb;34(2):199-202. doi: 10.1136/jcp.34.2.199.
Abstract
Five hundred and seven strains of bacteria isolated from the urine of patients with significant bacteriuria (more than 10(8) colony-forming units per litre) were tested for sensitivity to co-trimoxazole by the agar diffusion technique. Each organism was tested with a combined disk containing trimethoprim and sulphamethoxazole in a primary sensitivity test and, at a standardised inoculum, with both a combined disk and separate disks of trimethoprim and sulphamethoxazole. The results show that combined disk testing does not always indicate the sensitivity patterns of the organisms being tested.
摘要
采用琼脂扩散技术，对从有显著菌尿（每升超过10⁸菌落形成单位）患者尿液中分离出的507株细菌进行了复方新诺明敏感性检测。在初次敏感性试验中，每种微生物均用含有甲氧苄啶和磺胺甲恶唑的复合纸片进行检测，并在标准化接种量下，同时用复合纸片以及甲氧苄啶和磺胺甲恶唑的单独纸片进行检测。结果表明，复合纸片检测并不总是能显示被测微生物的敏感性模式。
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本文引用的文献
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J Bacteriol. 1950 Jul;60(1):17-28. doi: 10.1128/jb.60.1.17-28.1950.
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Synergistic activity of trimethoprim-sulfamethoxazole on gram-negative bacilli: observations in vitro and in vivo.甲氧苄啶-磺胺甲恶唑对革兰氏阴性杆菌的协同活性：体内外观察
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Failure to demonstrate an advantage in combining sulphamethoxazole with trimethoprim in an experimental model of urinary infection.在尿路感染实验模型中未能证明磺胺甲恶唑与甲氧苄啶联合使用具有优势。
J Clin Pathol. 1974 Aug;27(8):619-22. doi: 10.1136/jcp.27.8.619.
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Trimethoprim action and its analogy with thymine starvation.甲氧苄啶的作用及其与胸腺嘧啶饥饿的相似性。
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Comparison of laboratory methods in the diagnosis of urinary tract infection.诊断尿路感染的实验室方法比较
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