在尿路感染实验模型中未能证明磺胺甲恶唑与甲氧苄啶联合使用具有优势。
Failure to demonstrate an advantage in combining sulphamethoxazole with trimethoprim in an experimental model of urinary infection.
作者信息
Anderson J D, Lacey R W, Lewis E L, Sellin M A
出版信息
J Clin Pathol. 1974 Aug;27(8):619-22. doi: 10.1136/jcp.27.8.619.
Abstract
Co-trimoxazole was found to have a predominantly bacteriostatic effect upon 28 urinary isolates of Enterobacteriaceae in nutrient broth and was never bactericidal in artificially infected urine. The components of co-trimoxazole were tested individually and trimethoprim was found to be at least as effective as co-trimoxazole in nutrient broth and in urine. Trimethoprim alone produced some bactericidal effect in urine but this was antagonized by sulphamethoxazole. Laboratory tests for evaluating these drugs may give a misleading impression of their activity in vivo. Further clinical comparisons should therefore be made between trimethoprim and cotrimoxazole to determine when trimethoprim should be used in preference to the combination.
摘要
研究发现，复方新诺明对营养肉汤中28株肠杆菌科尿路分离菌主要起抑菌作用，在人工感染的尿液中从未表现出杀菌作用。对复方新诺明的成分进行了单独测试，结果发现甲氧苄啶在营养肉汤和尿液中的效果至少与复方新诺明一样好。单独使用甲氧苄啶在尿液中产生了一些杀菌作用，但这被磺胺甲恶唑拮抗。评估这些药物的实验室测试可能会对它们在体内的活性产生误导性印象。因此，应该对甲氧苄啶和复方新诺明进行进一步的临床比较，以确定何时应优先使用甲氧苄啶而非复方制剂。
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本文引用的文献
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Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital.甲氧苄啶-磺胺甲恶唑：医院内尿路感染的对比研究
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The in vitro demonstration of the efficacy of trimethoprim as an antibacterial agent in a comparative bacteriological study of the effects of trimethoprim, sulfamethoxazole and the combination trimethoprim-sulfamethoxazole.在一项关于甲氧苄啶、磺胺甲恶唑及甲氧苄啶-磺胺甲恶唑组合效果的比较细菌学研究中，对甲氧苄啶作为抗菌剂的疗效进行体外验证。
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Br Med J. 1972 Jun 17;2(5815):673-6. doi: 10.1136/bmj.2.5815.673.
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