Golden D B, Kagey-Sobotka A, Valentine M D, Lichtenstein L M
J Allergy Clin Immunol. 1981 May;67(5):370-4. doi: 10.1016/0091-6749(81)90082-8.
The clinical and immunologic efficacy of venom immunotherapy up to 50 micrograms maintenance doses (half the recommended dose) was examined in 23 patients with anaphylactic sensitivity to insect stings and is compared with that in two groups of patients treated with the full 100-micrograms recommended dose. Four of the 19 patients challenged with insect stings had mild systemic reactions not requiring treatment. This 79% clinical efficacy is significantly less than the 96% to 100% success achieved with treatment to full 100-micrograms maintenance doses. The venom-specific IgG antibody response to the 50-micrograms dose reached a level significantly lower than observed with 100 micrograms doses. We conclude that the clinical and immunologic responses to venom immunotherapy are dose dependent and are more reliably complete at the recommended maintenance dose of 100 micrograms of each venom than at a dose of 50 micrograms.
对23例对昆虫叮咬过敏的患者进行了研究，检测了毒液免疫疗法维持剂量达50微克（推荐剂量的一半）时的临床和免疫疗效，并与两组接受100微克推荐全剂量治疗的患者进行了比较。19例接受昆虫叮咬激发试验的患者中有4例出现轻度全身反应，无需治疗。这种79%的临床疗效明显低于使用100微克维持全剂量治疗所取得的96%至100%的成功率。对50微克剂量的毒液特异性IgG抗体反应达到的水平明显低于100微克剂量时观察到的水平。我们得出结论，毒液免疫疗法的临床和免疫反应是剂量依赖性的，与50微克剂量相比，每种毒液推荐维持剂量为100微克时，临床和免疫反应更可靠且更完全。
