Robbins S J, Wrzos H, Kline A L, Tenser R B, Rapp F
J Infect Dis. 1981 Mar;143(3):396-403. doi: 10.1093/infdis/143.3.396.
An infectious, cytopathic paramyxovirus was rescued from the peripheral blood leukocytes of a patient with subacute sclerosing panencephalitis (SSPE) by cocultivation procedures. Cells infected with the virus (1) demonstrated polykaryocytosis, (2) contained cytoplasmic inclusion bodies of paramyxoviral nucleocapsids, (3) hemadsorbed monkey erythrocytes, and (4) reacted with fluorescein-conjugated antisera to measles virus. On the basis of these observations, the virus was initially believed to be measles-like virus similar to those that have been rescued from other patients with SSPE. However, subsequent immunologic and molecular studies showed that the virus was distinct from measles virus and was more closely related to simian virus 5. These findings suggest that paramyxoviruses other than measles virus can be nonproductively carried by patients with SSPE and should not be designated as "measles like" or "measles related" solely on the basis of their biologic characteristics.
通过共培养程序，从一名亚急性硬化性全脑炎（SSPE）患者的外周血白细胞中拯救出一种具有感染性的、致细胞病变的副粘病毒。感染该病毒的细胞：（1）表现出多核细胞增多；（2）含有副粘病毒核衣壳的细胞质包涵体；（3）吸附猴红细胞；（4）与荧光素偶联的抗麻疹病毒抗血清发生反应。基于这些观察结果，该病毒最初被认为是类似于从其他SSPE患者中拯救出的麻疹样病毒。然而，随后的免疫学和分子研究表明，该病毒与麻疹病毒不同，与猴病毒5的关系更为密切。这些发现表明，除麻疹病毒外的副粘病毒可被SSPE患者非生产性携带，不应仅根据其生物学特性就将其指定为“麻疹样”或“与麻疹相关”。
