Rose D P, Leklem J E, Brown R R, Linkswiler H M
Am J Clin Nutr. 1975 Aug;28(8):872-8. doi: 10.1093/ajcn/28.8.872.
Oral glucose tolerance, urinary xanthurenic acid excretion, and plasma pyridoxal phosphate concentrations were determined in nine women taking oral contraceptives and in four controls. The tests were repeated after 4 weeks ingestion of a vitamin B6-deficient diet, and again after pyridoxine supplementation. Vitamin B6 deficiency, as judged by an increased xanthurenic acid excretion and reduced plasma pyridoxal phosphate, was associated with a deterioration in the glucose tolerance of the contraceptive steroid-treated group despite normal or elevated plasma insulin levels. This abnormality was reversed by pyridoxine. There was no change in the glucose tolerance of the vitamin B6-deficient controls. The observed pyridoxine-responsive alteration in carbohydrate metabolism may involve the complexing of insulin with xanthurenic acid with a consequent loss of biological activity. In addition, oral contraceptives may enhance gluconeogensis.
对9名服用口服避孕药的女性和4名对照者测定了口服葡萄糖耐量、尿中黄尿酸排泄量以及血浆磷酸吡哆醛浓度。在摄入缺乏维生素B6的饮食4周后重复进行测试，在补充吡哆醇后再次进行测试。根据黄尿酸排泄增加和血浆磷酸吡哆醛降低判断为维生素B6缺乏，这与避孕药类固醇治疗组的葡萄糖耐量恶化有关，尽管血浆胰岛素水平正常或升高。这种异常通过吡哆醇得以纠正。维生素B6缺乏的对照组的葡萄糖耐量没有变化。观察到的吡哆醇反应性碳水化合物代谢改变可能涉及胰岛素与黄尿酸的络合，从而导致生物活性丧失。此外，口服避孕药可能会增强糖异生作用。
