Prebis J W, Gruskin A B, Polinsky M S, Baluarte H J
J Pediatr. 1981 May;98(5):702-7. doi: 10.1016/s0022-3476(81)80828-1.
Serum uric acid concentrations and the fractional excretion of uric acid were determined in 31 children from 3 1/2 to 18 years of age with essential hypertension. While on an unrestricted sodium intake, elevated serum values of uric acid were found in 13 of 31 (42%) of the children. After ingesting a low-sodium diet (200 mg/day) for three days, mean serum uric acid values increased by 0.7 mg/dl (P less than 0.001). There was a significant inverse correlation between the serum uric acid concentrations and fractional excretion of uric acid during the normal and low-sodium diet. This study indicates that the major factor leading to hyperuricemia in our hypertensive patients was a decrease in urate clearance. Insofar as hyperuricemia may represent a cardiovascular risk factor, this abnormality already exists in a significant fraction of hypertensive children and adolescents.
对31名年龄在3.5岁至18岁的原发性高血压儿童测定了血清尿酸浓度和尿酸排泄分数。在钠摄入不受限制的情况下，31名儿童中有13名（42%）的血清尿酸值升高。在摄入低钠饮食（200毫克/天）三天后，平均血清尿酸值升高了0.7毫克/分升（P<0.001）。在正常饮食和低钠饮食期间，血清尿酸浓度与尿酸排泄分数之间存在显著的负相关。本研究表明，导致我们高血压患者高尿酸血症的主要因素是尿酸清除率降低。鉴于高尿酸血症可能是一种心血管危险因素，这种异常在相当一部分高血压儿童和青少年中已经存在。
