Goli Parvin, Riahi Roya, Daniali Seyede Shahrbanoo, Pourmirzaei Mohammadali, Kelishadi Roya
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2020 Apr 13;25:43. doi: 10.4103/jrms.JRMS_733_19. eCollection 2020.
Hyperuricemia is implicated in the pathogenesis of inflammatory diseases and metabolic disorders. Metabolic syndrome (MetS) in childhood is one of the most important causes of different noncommunicable diseases in adulthood. This study aimed to systematically review the association between serum uric acid (UA) concentration and components of pediatric MetS.
In this meta-analysis and systematic review, related articles were gathered by searching English databases including PubMed, Web of Science, Scopus, and Google Scholar. We used the following keywords: uric acid, metabolic syndrome, hypertension, fasting blood sugar (FBS), hyperglycemia; the search was limited to English language and included observational and cohort studies performed among children or adolescents. Pooled relative risks (odds ratio [OR]) and corresponding 95% confidence interval (95% CI) were extracted. A random-effect model was used.
On the basis of 34 eligible studies, the pooled correlation between UA with metabolic components including FBS (r = 0.24, 95% CI = 0.09-0.40), fasting insulin (r = 0.26, 95% CI = 0.15-0.37), and hyperglycemia (r for triglyceride and UA = 0.23, 95% CI = 0.19-0.38) (r for high-density lipoprotein and UA = -0.28, 95% CI = -0.37 to -0.20) was statistically significant. The association of both diastolic blood pressure (DBP) and systolic blood pressure (SBP) was statistically significant with UA (r for SBP and UA = 0.34, 95% CI = 0.24-0.43; r for DBP and UA = 0.18, 95% CI = 0.11-0.25). The OR between risk of abdominal obesity with UA was statistically significant (OR = 2.62, 95% CI = 1.41-3.84).
Serum UA concentration is associated with major components of the pediatric MetS. Its measurement and control should be underscored in at-risk children and adolescents.
高尿酸血症与炎症性疾病和代谢紊乱的发病机制有关。儿童代谢综合征（MetS）是成年期不同非传染性疾病的最重要原因之一。本研究旨在系统评价血清尿酸（UA）浓度与儿童MetS各组分之间的关联。
在这项荟萃分析和系统评价中，通过检索包括PubMed、Web of Science、Scopus和谷歌学术在内的英文数据库收集相关文章。我们使用了以下关键词：尿酸、代谢综合征、高血压、空腹血糖（FBS）、高血糖；检索仅限于英文文献，包括在儿童或青少年中进行的观察性研究和队列研究。提取合并相对风险（比值比[OR]）及相应的95%置信区间（95%CI）。采用随机效应模型。
基于34项符合条件的研究，UA与包括FBS（r = 0.24，95%CI = 0.09 - 0.40）、空腹胰岛素（r = 0.26，95%CI = 0.15 - 0.37）和高血糖（甘油三酯与UA的r = 0.23，95%CI = 0.19 - 0.38）（高密度脂蛋白与UA的r = -0.28，95%CI = -0.37至 -0.20）在内的代谢组分之间的合并相关性具有统计学意义。舒张压（DBP）和收缩压（SBP）与UA的关联均具有统计学意义（SBP与UA的r = 0.34，95%CI = 0.24 - 0.43；DBP与UA的r = 0.18，95%CI = 0.11 - 0.25）。腹部肥胖风险与UA之间的OR具有统计学意义（OR = 2.62，95%CI = 1.41 - 3.84）。
血清UA浓度与儿童MetS的主要组分相关。对于有风险的儿童和青少年，应强调对其进行检测和控制。
