Taylor C R, Maloiy G M, Weibel E R, Langman V A, Kamau J M, Seeherman H J, Heglund N C
Respir Physiol. 1981 Apr;44(1):25-37. doi: 10.1016/0034-5687(81)90075-x.
The purpose of this study was to determine whether the maximal rate of oxygen consumption (Vo2max) is scaled proportionally to Mb1.0, as the diffusing capacity of the lung, or proportionally to Mb0.75, as the standardized resting rate of oxygen consumption (V02std). We measured Vo2max on a variety of mammalian species (14 wild species and 8 domestic or laboratory species ranging in Mb from 7.2 g to 263 kg) using the same 'treadmill' procedure for all animals. For the wild species we found: Vo2max = 1.94.Mb0.79; r=0.995 where Vo2max has the units ml . sec-1 and mb is in kg. There was a great variability in Vo2max among domestic species of the same size, horse and dog having a Vo2max more than 3 times that of a cow and sheep, respectively. Both the variability in Vo2max with body size and among animals of the same size provide powerful tools for investigating the relationship between structure and function at each step in the respiratory system, from the oxygen in environmental air to the oxygen sink in the mitochondria.
本研究的目的是确定最大耗氧率（Vo2max）是与作为肺扩散能力的Mb1.0成比例缩放，还是与作为标准化静息耗氧率（V02std）的Mb0.75成比例缩放。我们使用相同的“跑步机”程序，对多种哺乳动物物种（14种野生动物和8种家养或实验动物物种，Mb范围从7.2克到263千克）测量了Vo2max。对于野生动物，我们发现：Vo2max = 1.94·Mb0.79；r = 0.995，其中Vo2max的单位为ml·sec-1，mb的单位为kg。相同体型的家养物种之间的Vo2max存在很大差异，马和狗的Vo2max分别比牛和羊高出3倍以上。Vo2max随体型的变化以及相同体型动物之间的变化，都为研究呼吸系统中从环境空气中的氧气到线粒体中的氧气汇这一过程中每个步骤的结构与功能之间的关系提供了有力工具。
