Mathieu O, Krauer R, Hoppeler H, Gehr P, Lindstedt S L, Alexander R M, Taylor C R, Weibel E R
Respir Physiol. 1981 Apr;44(1):113-28. doi: 10.1016/0034-5687(81)90079-7.
Since O2 is mainly consumed in muscle mitochondria during heavy physical work, one would expect to find a relationship between the volume density of mitochondria in skeletal muscles and maximal O2 uptake. We analyzed the volume density of mitochondria, Vv(mt,f) in four muscles of a series of African mammals ranging in body mass from 0.4 to 251 kg. Vv(mt,f) scaled as Mb-0.231, Mb-0.163, Mb-0.139 and Mb-0.055 in Mm. semitendinosus, longissimus dorsi, vastus medialis and diaphragm, respectively. The mass or volume of diaphragm was found to scale as Mb0.865, whereas for Mm. semitendinosus and vastus medialis, muscle volume (Vmu) scaled as Mb1.030 and Mb0.956 respectively. Scaling the absolute volume of mitochondria Vmt, in these muscles (Vmt = Vv (mt,f) x Vmu) against Mb gives regression lines whose slopes closely parallel that obtained for Vo2max against body mass. Therefore the ratio of volume of mitochondria in these muscles to Vo2max is body mass independent.
由于在繁重的体力劳动中，氧气主要在肌肉线粒体中被消耗，因此人们可能会预期在骨骼肌中线粒体的体积密度与最大摄氧量之间存在某种关系。我们分析了一系列体重从0.4千克到251千克的非洲哺乳动物的四块肌肉中线粒体的体积密度Vv(mt,f)。在半腱肌、背最长肌、股内侧肌和膈肌中，Vv(mt,f)分别与体重呈Mb-0.231、Mb-0.163、Mb-0.139和Mb-0.055的比例关系。发现膈肌的质量或体积与体重呈Mb0.865的比例关系，而对于半腱肌和股内侧肌，肌肉体积（Vmu）分别与体重呈Mb1.030和Mb0.956的比例关系。将这些肌肉中线粒体的绝对体积Vmt（Vmt = Vv(mt,f)×Vmu）与体重进行比例换算，得到的回归线斜率与最大摄氧量与体重的回归线斜率非常接近。因此，这些肌肉中线粒体体积与最大摄氧量的比值与体重无关。
