Könemann H
Toxicology. 1981;19(3):209-21. doi: 10.1016/0300-483x(81)90130-x.
LC50-experiments have been conducted using guppies subjected to 72 industrial pollutants. The correlation of the LC50 with several expressions of the hydrophobicity of these chemicals has been studied. Calculated log Poct-values appeared to satisfy more than HPLC retention indices, solubility data or molecular connectivity indices. One QSAR, with log Poct as the only variable, gave good estimations of the toxicity of most of the tested compounds with log Poct less than 6. No LC50 could be determined for solutions of compounds with log Poct greater than 6.
已使用孔雀鱼对72种工业污染物进行了半数致死浓度（LC50）实验。研究了这些化学品的LC50与疏水性的几种表达之间的相关性。计算得到的正辛醇/水分配系数对数值（log Poct）似乎比高效液相色谱保留指数、溶解度数据或分子连接性指数更符合要求。一个以log Poct作为唯一变量的定量构效关系（QSAR），对大多数log Poct小于6的受试化合物的毒性给出了良好的估计。对于log Poct大于6的化合物溶液，无法确定其LC50。
