Alroy J, Gould V E
Ultrastruct Pathol. 1980 Apr-Jun;1(2):201-10. doi: 10.3109/01913128009141417.
The ultrastructure of the epithelial-stromal interface of the human urinary bladder was studied in biopsy specimens that included 7 normal controls, 1 inverted papilloma, 18 noninvasive papillary carcinomas, and 19 invasive transitional cell carcinomas. In the invasive foci of the transitional cell carcinomas, the underlying basal lamina was attenuated or absent and the number of hemidesmosomes was decreased. These neoplastic cells displayed notably increased numbers of lysosomes, some of which appeared to be in the process of exocytosis. Increased numbers of cytoplasmic filaments adjacent to the plasma membranes at the invading pole of these cells were also observed. Tight junctions and junctional complexes were noticed adjacent to the tumor-stromal interface. None of the aforementioned features was observed in normal transitional epithelium, in inverted papilloma, in noninvasive papillary carcinomas, or in the noninvasive portions of invasive transitional cell carcinomas. Alterations of the epithelial-stromal interface deserve additional studies for they may constitute important parameters in the evaluation of actual or potential invasiveness in the various types of carcinoma of the bladder.
在活检标本中研究了人类膀胱上皮-间质界面的超微结构，这些标本包括7例正常对照、1例内翻性乳头状瘤、18例非浸润性乳头状癌和19例浸润性移行细胞癌。在移行细胞癌的浸润灶中，其下方的基膜变薄或缺失，半桥粒数量减少。这些肿瘤细胞显示溶酶体数量显著增加，其中一些似乎处于胞吐过程中。在这些细胞浸润极的质膜附近还观察到细胞质细丝数量增加。在肿瘤-间质界面附近发现了紧密连接和连接复合体。在正常移行上皮、内翻性乳头状瘤、非浸润性乳头状癌或浸润性移行细胞癌的非浸润部分均未观察到上述特征。上皮-间质界面的改变值得进一步研究，因为它们可能是评估各种类型膀胱癌实际或潜在侵袭性的重要参数。
