Alroy J, Pauli B U, Weinstein R S
Cancer. 1981 Jan 1;47(1):104-12. doi: 10.1002/1097-0142(19810101)47:1<104::aid-cncr2820470118>3.0.co;2-8.
Quantitative electron microscopy has been used to examine the correlation between numbers of desmosomes and the histopathological grade and stage of papillary transitional cell carcinomas in human urinary bladder. Numbers of desmosomes (desmosomal density) per 100 micrometers of cell perimeter were quantitated in 6 examples of normal epithelium, 11 noninvasive papillary transitional cell carcinomas, 8 invasive transitional cell carcinomas arising from papillary lesions, 3 invasive transitional cell carcinomas which had prominent foci of glandular and squamous differentiation, and 1 squamous cell carcinoma. Desmosomal densities were increased in noninvasive transitional cell carcinomas, as compared with normal epithelium, but decreased in invasive transitional cell carcinomas. However, in areas of glandular or squamous differentiation in invasive tumors, desmosomal densities were increased, possibly reflecting the changes in cell phenotype. The decrease in numbers of desmosomes in invasive transitional cell carcinomas may contribute to reductions in cell adhesiveness.
定量电子显微镜已被用于研究人膀胱乳头状移行细胞癌中桥粒数量与组织病理学分级和分期之间的相关性。对6例正常上皮、11例非侵袭性乳头状移行细胞癌、8例起源于乳头状病变的侵袭性移行细胞癌、3例具有显著腺性和鳞状分化灶的侵袭性移行细胞癌以及1例鳞状细胞癌，每100微米细胞周长的桥粒数量（桥粒密度）进行了定量分析。与正常上皮相比，非侵袭性移行细胞癌的桥粒密度增加，但侵袭性移行细胞癌的桥粒密度降低。然而，在侵袭性肿瘤的腺性或鳞状分化区域，桥粒密度增加，这可能反映了细胞表型的变化。侵袭性移行细胞癌中桥粒数量的减少可能导致细胞黏附性降低。
