Orr W C, Males J L, Imes N K
Am J Med. 1981 May;70(5):1061-6. doi: 10.1016/0002-9343(81)90867-6.
Three cases of hypersomnolence, snoring and documented sleep apnea are reported. All three patients were profoundly myxedematous, both clinically and biochemically. Polygraphic studies during sleep documented the presence of repetitive episodes of obstructive sleep apnea in all three patients. These were accompanied by arterial oxygen desaturation. After becoming euthyroid following the administration of the l-thyroxine all patients underwent a repeat evaluation in the sleep laboratory. These studies revealed nearly complete resolution of obstructive sleep apnea in all patients. In addition, several sleep parameters showed marked improvement. These data strongly suggest that the presence of profound daytime sleepiness in hypothyroid patients could be indicative of a potentially lethal complication of myxedema, obstructive sleep apnea.
报告了3例嗜睡、打鼾且有记录的睡眠呼吸暂停病例。所有3例患者在临床和生化方面均有严重黏液性水肿。睡眠期间的多导睡眠图研究记录了所有3例患者均存在阻塞性睡眠呼吸暂停的反复发作。这些发作伴有动脉血氧饱和度下降。在给予左旋甲状腺素后甲状腺功能恢复正常，所有患者均在睡眠实验室接受了再次评估。这些研究显示所有患者的阻塞性睡眠呼吸暂停几乎完全缓解。此外，多项睡眠参数有显著改善。这些数据强烈表明，甲状腺功能减退患者出现严重的日间嗜睡可能预示着黏液性水肿的一种潜在致命并发症——阻塞性睡眠呼吸暂停。
