Fine B S, Yanoff M, Stone R A
Am J Ophthalmol. 1981 Jan;91(1):88-105. doi: 10.1016/0002-9394(81)90353-6.
Eight eyes obtained at autopsy from four patient who had chronic open-angle glaucoma were compared to eyes with normal aging changes. Three cases were characterized by early and pronounced abnormalities in the uveal portion of the drainage angle. The findings consisted of formation of an exaggerated scleral spur upon the scleral roll by accretion and compaction of the overlying uveal meshwork, hyalinization and atrophy of the adjacent ciliary muscle, and atrophy of the iris root. The fourth case showed widespread proliferation of endothelium into the lumen of Schlemm's canal. We concluded that the predominant histologic findings in eyes with open-angle glaucoma consists of an exaggeration of normal aging processes, ranging in a spectrum from excessive involvement of the uveal pathway to excessive involvement of the canal of Schlemm pathway.
从四名患有慢性开角型青光眼的患者尸检中获取的八只眼睛与具有正常衰老变化的眼睛进行了比较。三例的特征是引流角的葡萄膜部分出现早期且明显的异常。这些发现包括通过覆盖其上的葡萄膜小梁网的增生和压实，在巩膜嵴上形成过度增大的巩膜突，相邻睫状肌的玻璃样变性和萎缩，以及虹膜根部的萎缩。第四例显示内皮细胞广泛增生进入施莱姆管腔。我们得出结论，开角型青光眼眼睛的主要组织学发现是正常衰老过程的过度表现，范围从葡萄膜途径的过度受累到施莱姆管途径的过度受累。
