Ann Intern Med. 1981 May;94(5):667-77. doi: 10.7326/0003-4819-94-5-667.
A retrospective analysis of the course of systemic lupus erythematosus in pregnant patients hospitalized at UCLA during a 15-year period provided important prognostic information. Women with systemic lupus erythematosus became pregnant if renal function was reasonably well preserved. Pregnancy infrequently posed a serious threat to the mother; the frequency of nonrenal complications in patients with systemic lupus erythematosus was very low, and the frequency of permanent deterioration of renal function was less than 10%. In contrast, the fetus was at high risk and was adversely affected even if mild renal involvement was detected in the mother. The prevalence of neonatal complications did not increase in the newborn; however, growth retardation did occur in the immediate neonatal period. The pharmacologic management of systemic lupus erythematosus does not require any important modifications in pregnant patients. During labor and in the postpartum period, however, an increase in the dosage of glucocorticoids may reduce postpartum exacerbations.
对15年间在加州大学洛杉矶分校住院的狼疮患者孕期病程进行回顾性分析，提供了重要的预后信息。狼疮患者若肾功能得到合理良好的维持则可怀孕。怀孕很少对母亲构成严重威胁；狼疮患者非肾脏并发症的发生率很低，肾功能永久性恶化的发生率不到10%。相比之下，胎儿处于高风险中，即使母亲仅有轻度肾脏受累也会受到不利影响。新生儿并发症的发生率在新生儿中并未增加；然而，在新生儿早期确实会出现生长发育迟缓。狼疮的药物治疗在孕期患者中无需进行任何重大调整。然而，在分娩期间及产后，增加糖皮质激素的剂量可能会减少产后病情加重。
