Petri M
Division of Molecular and Clinical Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rheum Dis Clin North Am. 1994 Feb;20(1):87-118.
Although most women with systemic lupus erythematosus can achieve a successful pregnancy, fetal (fetal loss, preterm birth) and maternal (lupus flares, worsening renal function) morbidity remain major problems. Predictors of fetal loss and preterm birth have been identified and are reviewed. Modern management of lupus pregnancy includes identification of high-risk pregnancies with appropriate monitoring and treatment (when indicated) for anti-Ro and antiphospholipid antibodies, frequent assessment of and control of maternal lupus activity, adjustment of medications to avoid those associated with fetal teratogenicity, and the appropriate use of fetal assessment tests to guide intervention for the fetus at risk of intrauterine death.
尽管大多数系统性红斑狼疮女性能够成功妊娠，但胎儿（胎儿丢失、早产）和母体（狼疮发作、肾功能恶化）的发病率仍然是主要问题。胎儿丢失和早产的预测因素已被确定并进行了综述。狼疮妊娠的现代管理包括识别高危妊娠，对抗Ro和抗磷脂抗体进行适当监测和治疗（如有指征），频繁评估和控制母体狼疮活动，调整药物以避免使用与胎儿致畸性相关的药物，以及适当使用胎儿评估测试来指导对有宫内死亡风险的胎儿进行干预。
