Gillenberg A, Immel C, Orfanos C E
Arch Dermatol Res. 1980;269(3):331-5. doi: 10.1007/BF00406428.
In 21 healthy volunteers (18-48 years old) autoradiographic studies were performed before, 3 and 7 days after oral administration of aromatic retinoid Ro 10-9359 (75 mg/d) and after oral intake of placebo. After retinoid the 3H-thymidine labelling index was significantly increased, whereas the DNA synthesis time and the cell cycle time were decreased. After placebo no change in epidermal cell kinetic parameters were registered. These findings indicate that therapeutic doses of oral aromatic retinoid clearly stimulate epidermal cell proliferation in normal human epidermis.
在21名健康志愿者（18 - 48岁）中，在口服芳香维甲酸Ro 10 - 9359（75毫克/天）之前、之后3天和7天以及口服安慰剂之后进行了放射自显影研究。服用维甲酸后，3H - 胸腺嘧啶核苷标记指数显著增加，而DNA合成时间和细胞周期时间缩短。服用安慰剂后，表皮细胞动力学参数未见变化。这些发现表明，口服芳香维甲酸的治疗剂量能明显刺激正常人表皮中的表皮细胞增殖。
