Hansen J C, Kristensen P
Arch Toxicol. 1980 Dec;46(3-4):273-6. doi: 10.1007/BF00310444.
Pretreatment with zinc does not change the wholebody retention and elimination of mercury, either when mercury is given alone, or when mercury and selenium are given simultaneously in single doses. Distributional effects are observed, however, as higher retention levels of mercury are seen in kidneys, liver and spleen after pretreatment with zinc. The clearance rate of both elements remains unaffected, indicating that zinc does not truly interact with mercury and selenium. The zinc effect is probably due to a higher initial retention of mercury, especially in the kidneys.
单独给予汞,或同时单剂量给予汞和硒时,锌预处理均不会改变汞在全身的潴留和消除情况。然而,观察到了分布效应,因为锌预处理后,肾脏、肝脏和脾脏中汞的潴留水平更高。两种元素的清除率均未受影响,这表明锌并未真正与汞和硒发生相互作用。锌的作用可能是由于汞的初始潴留增加,尤其是在肾脏中。