Nirankari V S, Varma S D, Lakhanpal V, Richards R D
Arch Ophthalmol. 1981 May;99(5):886-7. doi: 10.1001/archopht.1981.03930010886020.
To test the hypothesis that superoxide radicals are involved in tissue destruction after alkali burns, superoxide dismutase, ascorbic acid, and glutathione were used as superoxide radical scavenging agents. Daily subconjunctival injections were given in rabbit eyes after alkali burns. Both superoxide dismutase and ascorbic acid were effective in preventing corneal perforations. Glutathione did not show any beneficial effect. These experiments suggest that superoxide radical scavenging agents may be useful in the treatment of ocular alkali burns.
为了验证超氧阴离子自由基参与碱烧伤后组织破坏这一假说，将超氧化物歧化酶、抗坏血酸和谷胱甘肽用作超氧阴离子自由基清除剂。碱烧伤后每日对兔眼进行结膜下注射。超氧化物歧化酶和抗坏血酸在预防角膜穿孔方面均有效。谷胱甘肽未显示出任何有益效果。这些实验表明，超氧阴离子自由基清除剂可能对眼部碱烧伤的治疗有用。
