Sperduto R D, Hiller R, Seigel D
Arch Ophthalmol. 1981 Jun;99(6):1004-8. doi: 10.1001/archopht.1981.03930011004003.
Analysis of data from a population survey, the Framingham Eye Study, shows that when the various senile lens changes are pooled, no associations with senile maculopathy are evident. Subgroup analysis shows the relative risk of senile maculopathy to be lower than 1.00 in the presence of nuclear sclerosis for all age groups and greater than 1.00 for persons between 52 and 74 years in the presence of cortical changes. Nuclear-cortical interaction tests are highly significant, indicating that nuclear sclerosis and cortical opacities have opposite effects on the relative risk of senile maculopathy.
对一项人群调查——弗雷明汉姆眼研究的数据进行分析后发现，当将各种老年性晶状体变化汇总在一起时，与老年性黄斑病变并无明显关联。亚组分析显示，在所有年龄组中，存在核硬化时老年性黄斑病变的相对风险低于1.00；而在52至74岁人群中，存在皮质变化时该相对风险则高于1.00。核 - 皮质相互作用测试具有高度显著性，表明核硬化和皮质混浊对老年性黄斑病变的相对风险具有相反的影响。
