Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, 17 Hougou Lane, Chong Wen Men, 100005, Beijing, China.
Graefes Arch Clin Exp Ophthalmol. 2011 Jul;249(7):981-5. doi: 10.1007/s00417-010-1571-y. Epub 2010 Dec 21.
To examine in an intra-individual comparison whether cataract is associated with age-related macular degeneration (AMD).
The population-based Beijing Eye Study included 4,439 subjects (age: 40+ years) out of 5,324 subjects invited to be examined. Using lens and fundus photographs, the amount of AMD was graded according to the Wisconsin Age-Related Maculopathy Grading system and the degree of cataract was graded using the system of the Age-Related Eye Disease Study.
Photographs with sufficient quality for bilateral examination of the lens and macula were available for 3,826 (86.2%) participants with a mean age of 55.3 ± 10.0 years (range: 40-90 years) and a mean refractive error of -0.38 ± 2.18 diopters (range: -20.13 diopters to +7.50 diopters). The side difference in presence of early AMD and late AMD respectively was not significantly associated with the inter-eye difference in the amount of nuclear cataract [P = 0.27 and P = 0.28 (r = 0.02) respectively), amount of cortical cataract (P = 0.12 and P = 0.05 respectively), and amount of subcapsular posterior cataract (P = 0.91 and P = 0.85 respectively). In a similar manner, the side difference in the presence of early AMD and late AMD was not significantly associated with the inter-eye difference in the presence of nuclear cataract (P = 0.99 and P = 0.99 respectively), cortical cataract (P = 0.25 and P = 1.00 respectively), and subcapsular posterior cataract (P = 0.59 and P = 0.05 respectively). The side difference in the number of macular drusen was not significantly associated with the inter-eye difference in the amount of nuclear cataract (P = 0.74), amount of cortical cataract (P = 0.19) and amount of subcapsular posterior cataract (P = 0.88). As a corollary, unilateral pseudophakia or aphakia was not significantly associated with inter-eye differences in the count (P = 0.59) of drusen, and overall presence of early AMD (P = 0.99) or late AMD (P = 0.99).
In an intra-individual, inter-eye comparison, avoiding interdependencies of systemic parameters, inter-eye difference was not significantly associated with any characteristics of age-related macular degeneration in either any type of cataract or in pseudophakia. This suggests that the development of cataract or cataract surgery did not markedly influence the development of age-related macular degeneration.
在个体内比较中，检查白内障是否与年龄相关性黄斑变性（AMD）有关。
基于人群的北京眼研究纳入了 5324 名受邀接受检查的受试者中的 4439 名（年龄：40 岁以上）。使用晶状体和眼底照片，根据威斯康星州年龄相关性黄斑病变分级系统对 AMD 的程度进行分级，并使用年龄相关性眼病研究系统对白内障的程度进行分级。
对于具有双侧晶状体和黄斑检查足够质量的照片的 3826 名（86.2%）参与者，平均年龄为 55.3±10.0 岁（范围：40-90 岁），平均屈光度为-0.38±2.18 屈光度（范围：-20.13 屈光度至+7.50 屈光度）。早期 AMD 和晚期 AMD 的双侧差异与核性白内障[P=0.27 和 P=0.28（r=0.02）]、皮质性白内障（P=0.12 和 P=0.05）以及后囊下皮质白内障的眼间差异无显著相关性（P=0.91 和 P=0.85）。同样，早期 AMD 和晚期 AMD 的双侧差异与核性白内障（P=0.99 和 P=0.99）、皮质性白内障（P=0.25 和 P=1.00）以及后囊下皮质白内障（P=0.59 和 P=0.05）的眼间差异无显著相关性。黄斑盘状斑的数量的双侧差异与核性白内障（P=0.74）、皮质性白内障（P=0.19）和后囊下皮质白内障（P=0.88）的眼间差异无显著相关性。作为推论，单侧假性晶状体或无晶状体并不显著与盘状斑的计数（P=0.59）或早期 AMD（P=0.99）或晚期 AMD（P=0.99）的眼间差异相关。
在个体内、眼间比较中，避免系统性参数的相互依赖性，眼间差异与任何类型的白内障或假性晶状体中的年龄相关性黄斑变性的任何特征均无显著相关性。这表明白内障的发展或白内障手术并未明显影响年龄相关性黄斑变性的发展。
