Klein R, Klein B E, Wang Q, Moss S E
Department of Ophthalmology, University of Wisconsin, Madison.
Arch Ophthalmol. 1994 Feb;112(2):191-6. doi: 10.1001/archopht.1994.01090140067025.
To evaluate the relationship between three types of cataract or cataract surgery and age-related maculopathy.
Population-based prevalence study.
A total of 4926 people participating in The Beaver Dam Eye Study from 1988 through 1990.
Grading of photographs for nuclear sclerosis, cortical cataract, and posterior subcapsular cataract and signs of age-related maculopathy was performed using standardized protocols.
After adjusting for other risk factors, nuclear sclerosis was associated with increased odds of early age-related maculopathy (odds ratio [OR], 1.96; 95% confidence interval [CI], 1.28 to 3.01) but not of late age-related maculopathy (OR, 1.38; 95% CI, 0.52 to 3.63). Neither cortical nor posterior subcapsular cataracts were related to age-related maculopathy. There were increased odds of early age-related maculopathy in eyes that had undergone cataract surgery.
These data suggest a possible commonly shared pathogenesis between nuclear sclerotic cataract and age-related maculopathy.
评估三种类型的白内障或白内障手术与年龄相关性黄斑病变之间的关系。
基于人群的患病率研究。
共有4926人参与了1988年至1990年的比弗迪尔姆眼研究。
使用标准化方案对核性硬化、皮质性白内障和后囊下白内障的照片进行分级，并评估年龄相关性黄斑病变的体征。
在对其他危险因素进行校正后，核性硬化与早期年龄相关性黄斑病变的患病几率增加相关（优势比[OR]，1.96；95%置信区间[CI]，1.28至3.01），但与晚期年龄相关性黄斑病变无关（OR，1.38；95%CI，0.52至3.63）。皮质性白内障和后囊下白内障均与年龄相关性黄斑病变无关。接受白内障手术的眼睛发生早期年龄相关性黄斑病变的几率增加。
这些数据表明核性硬化性白内障与年龄相关性黄斑病变之间可能存在共同的发病机制。
