在一段蛋白质饥饿期后，肝脏核糖体的转录增加以及降解减少可控制并促进其恢复。
Increased transcription and decreased degradation control and recovery of liver ribosomes after a period of protein starvation.
作者信息
Conde R D, Franze-Fernández M T
出版信息
Biochem J. 1980 Dec 15;192(3):935-40. doi: 10.1042/bj1920935.
Abstract
In the livers of 5-days-protein-depleted mice there is a decrease of 47% of the ribosome mass. When these animals are fed with an adequate diet, ribosome content is restored to the normal value after 1 day of re-feeding. The mechanisms underlying this phenomenon were studied. It was found that: (1) the activity of RNA polymerase I in the nuclei of livers from re-fed animals showed an enhancement of about 2-fold compared with the activity in normal and protein-depleted liver nuclei; (2) ribosome degradation, measured by the disappearance of radioactivity from ribosomal proteins previously labelled by the administration of NaH14CO3 to the mice, stopped during the first day after re-feeding.
摘要
在蛋白质缺乏5天的小鼠肝脏中，核糖体质量减少了47%。当给这些动物喂食充足的食物后，再喂食1天后核糖体含量恢复到正常值。对这一现象的潜在机制进行了研究。结果发现：（1）与正常和蛋白质缺乏的肝脏细胞核相比，再喂食动物肝脏细胞核中RNA聚合酶I的活性增强了约2倍；（2）通过给小鼠注射NaH14CO3预先标记核糖体蛋白后，核糖体蛋白放射性消失来衡量的核糖体降解，在再喂食后的第一天就停止了。
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Ribosome formation in HeLa cells in the absence of protein synthesis.在缺乏蛋白质合成的情况下，HeLa细胞中的核糖体形成。
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