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进食和饥饿大鼠线粒体中丙二酰辅酶A对生酮作用的差异抑制

Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.

作者信息

Cook G A, Otto D A, Cornell N W

出版信息

Biochem J. 1980 Dec 15;192(3):955-8. doi: 10.1042/bj1920955.

DOI:10.1042/bj1920955
PMID:7236248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162424/
Abstract

Rates of ketogenesis in mitochondria from fed or starved rats were identical at optimal substrate concentrations, but responded differently to inhibition by malonyl-CoA. Kinetic data suggest that the K1 for malonyl-CoA is greater in the starved animal. These results indicate that, for the regulation of ketogenesis in the starved state, the lower sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA may be more important than the concentration of malonyl-CoA.

摘要

在最佳底物浓度下，喂食或饥饿大鼠线粒体中的生酮速率相同，但对丙二酸单酰辅酶A抑制的反应不同。动力学数据表明，饥饿动物中丙二酸单酰辅酶A的K1更大。这些结果表明，对于饥饿状态下的生酮调节，肉碱棕榈酰转移酶对丙二酸单酰辅酶A抑制的较低敏感性可能比丙二酸单酰辅酶A的浓度更重要。

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1
Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.进食和饥饿大鼠线粒体中丙二酰辅酶A对生酮作用的差异抑制
Biochem J. 1980 Dec 15;192(3):955-8. doi: 10.1042/bj1920955.
2
Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats.实验条件在评估肝脏肉碱酰基转移酶丙二酸单酰辅酶A敏感性中的重要性。对喂食和饥饿大鼠的研究。
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Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.进食或饥饿大鼠肝脏分离线粒体中丙二酰辅酶A对肉碱棕榈酰转移酶I抑制作用的时间依赖性。该酶对丙二酰辅酶A的低亲和力和高亲和力状态之间转变的证据。
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Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.肝脏中丙二酰辅酶A对长链脂肪酸氧化调节作用的评估。该系统存在未知调节成分的证据。
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Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.丙二酰辅酶A对肉碱棕榈酰转移酶抑制作用中的滞后效应参与情况。
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本文引用的文献

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Factors influencing the rates of long-chain fatty acid oxidation and synthesis in mammalian systems.影响哺乳动物系统中长链脂肪酸氧化和合成速率的因素。
Physiol Rev. 1961 Jan;41:52-129. doi: 10.1152/physrev.1961.41.1.52.
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Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.肝脏中丙二酰辅酶A对长链脂肪酸氧化调节作用的评估。该系统存在未知调节成分的证据。
Biochem J. 1980 Dec 15;192(3):959-62. doi: 10.1042/bj1920959.
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The effect of fasting on esterification of palmitate by rat liver in vitro.
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Aspects of ketogenesis: control and mechanism of ketone-body formation in isolated rat-liver mitochondria.生酮作用的各个方面：大鼠离体肝脏线粒体中酮体生成的调控与机制
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Effects of lactation of ketogenesis from oleate or butyrate in rat hepatocytes.大鼠肝细胞中油酸或丁酸生酮作用的泌乳效应。
Biochem J. 1977 Jun 15;164(3):521-8. doi: 10.1042/bj1640521.
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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.丙二酰辅酶A在肝脏脂肪酸氧化和酮体生成调节中的可能作用。
J Clin Invest. 1977 Jul;60(1):265-70. doi: 10.1172/JCI108764.
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Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats.关于进食状态下未孕大鼠和泌乳大鼠肝细胞中脂肪生成与酮体生成之间相互关系的证据。
Biochem J. 1978 Oct 15;176(1):331-4. doi: 10.1042/bj1760331.