进食和饥饿大鼠线粒体中丙二酰辅酶A对生酮作用的差异抑制
Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.
作者信息
Cook G A, Otto D A, Cornell N W
出版信息
Biochem J. 1980 Dec 15;192(3):955-8. doi: 10.1042/bj1920955.
Abstract
Rates of ketogenesis in mitochondria from fed or starved rats were identical at optimal substrate concentrations, but responded differently to inhibition by malonyl-CoA. Kinetic data suggest that the K1 for malonyl-CoA is greater in the starved animal. These results indicate that, for the regulation of ketogenesis in the starved state, the lower sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA may be more important than the concentration of malonyl-CoA.
摘要
在最佳底物浓度下，喂食或饥饿大鼠线粒体中的生酮速率相同，但对丙二酸单酰辅酶A抑制的反应不同。动力学数据表明，饥饿动物中丙二酸单酰辅酶A的K1更大。这些结果表明，对于饥饿状态下的生酮调节，肉碱棕榈酰转移酶对丙二酸单酰辅酶A抑制的较低敏感性可能比丙二酸单酰辅酶A的浓度更重要。
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