Mukuno K, Ishikawa S, Okamura R
Br J Ophthalmol. 1981 Apr;65(4):284-90. doi: 10.1136/bjo.65.4.284.
Thirty cases of Minamata disease caused by methyl mercury poisoning with the lesion mainly at the occipital cortex were selected and their spatial contrast sensitivity of vision was examined by the Arden grating chart. At the same time their visual acuity, visual field, and visual evoked cortical potential (VECP) were also investigated. In all cases the results of the Arden test indicated abnormality. Poor results were obtained at higher frequencies of the gratings. VECP elicited by grating pattern reversal stimulus was undertaken in 12 cases out of the 30. The results revealed abnormality almost equal to that shown by the Arden test. Seven out of the 12 cases showed no VECP response. The other 5, giving a response, showed abnormality: when the size of the grating became smaller at higher frequencies, the VECP paused or was not recorded, whereas at low frequencies it was recorded. This finding was in good agreement or was not recorded, whereas at low frequencies it was recorded. This finding was in good agreement with the results of the Arden test. Visual acuity and visual field tests were less sensitive in detecting abnormality. The Arden chart is a sensitive clinical tool for patients with lesions at the cerebral cortex. Furthermore, the test can be used for screening patients who may have come in contrast with organic mercury.
选取30例主要病变位于枕叶皮质的甲基汞中毒所致水俣病患者，采用 Arden 光栅图检查其视觉空间对比敏感度。同时，对其视力、视野和视觉诱发电位（VECP）也进行了研究。所有病例的 Arden 试验结果均显示异常。在光栅频率较高时，结果较差。30例患者中有12例进行了光栅图形反转刺激诱发的 VECP 检查。结果显示异常情况与 Arden 试验几乎相同。12例中有7例未出现 VECP 反应。另外5例有反应的患者显示异常：当光栅频率较高且尺寸变小时，VECP 暂停或未记录到，而在低频时则可记录到。这一发现与 Arden 试验结果高度一致。视力和视野检查在检测异常方面不太敏感。Arden 图表是检测大脑皮质病变患者的一种敏感的临床工具。此外，该试验可用于筛查可能接触过有机汞的患者。
