Meyhoff H H, Nordling J
Br J Urol. 1981 Apr;53(2):129-33. doi: 10.1111/j.1464-410x.1981.tb03150.x.
The effect of 4 weeks' treatment with emepronium bromide in 20 incontinent female patients with detrusor hyperreflexia was compared to the effect in 20 patients who did not have uninhibited detrusor contractions during filling cystometry but who were unable to suppress a voluntarily induced detrusor contraction. In both groups, 65% benefited from the drug and no statistically significant differences were seen in the decrease in frequency of voiding and incontinence episodes during treatment. There were no differences between the groups for age, type and degree of urinary incontinence, and radiological findings of bladder suspension defects. In these patients it is important to perform cystometry, including detrusor reflex activation procedures and the testing of their ability to suppress a voluntarily induced detrusor contraction.
将20名患有逼尿肌反射亢进的尿失禁女性患者使用溴乙胺太林治疗4周的效果，与20名在膀胱测压充盈期无逼尿肌无抑制性收缩但无法抑制自主诱发的逼尿肌收缩的患者的治疗效果进行了比较。在两组中，65%的患者从药物治疗中获益，治疗期间排尿频率和尿失禁发作次数的减少在统计学上无显著差异。两组在年龄、尿失禁类型和程度以及膀胱悬吊缺陷的影像学检查结果方面均无差异。对这些患者而言，进行膀胱测压很重要，包括逼尿肌反射激活程序以及测试其抑制自主诱发逼尿肌收缩的能力。
