硫喷妥钠和阿法沙辛对琥珀酰胆碱诱发的肌束震颤和肌痛的影响。

The influence of thiopentone and alfathesin on succinylcholine-induced fasciculations and myalgias.

作者信息

Manani G, Valenti S, Segatto A, Angel A, Meroni M, Giron G P

出版信息

Can Anaesth Soc J. 1981 May;28(3):253-8. doi: 10.1007/BF03005510.

Abstract

Thiopentone doses corresponding to 5.238 mg x kg-1, that is 2UD95 (UD95:unconsciousness dose 95) inhibit the intensity of succinylcholine-induced fasciculations compared with UD95. Alfathesin doses corresponding to 0.570 mg x kg-1, also 2UD95 (calculated as alphaxalone at a concentration of 9 mg/ml in alfathesin), do not have any greater effect on the degree of fasciculations compared to UD95. Furthermore, neither induction agent influences the incidence, distribution and duration of succinylcholine-induced myalgias. The inhibition of the degree of fasciculations caused by thiopentone is believed to be a consequence of a postsynaptic depressant effect of thiopentone at the neuromuscular junction. The evaluation of the degree of succinylcholine-induced fasciculations must take into consideration the dose of thiopentone administered at induction of anaesthesia.

摘要

与5.238毫克×千克⁻¹相当的硫喷妥钠剂量，即2UD95（UD95：95%意识消失剂量），与UD95相比，可抑制琥珀酰胆碱诱导的肌束颤动强度。与0.570毫克×千克⁻¹相当的阿法沙辛剂量，同样为2UD95（按阿法沙辛中浓度为9毫克/毫升的阿法沙龙计算），与UD95相比，对肌束颤动程度没有更大影响。此外，两种诱导剂均不影响琥珀酰胆碱诱导的肌痛的发生率、分布和持续时间。硫喷妥钠对肌束颤动程度的抑制被认为是硫喷妥钠在神经肌肉接头处的突触后抑制作用的结果。评估琥珀酰胆碱诱导的肌束颤动程度时必须考虑麻醉诱导时给予的硫喷妥钠剂量。