Yap H Y, Blumenschein G R, Schell F, Bodey G P
Cancer Treat Rep. 1981 May-Jun;65(5-6):465-7.
Twenty-nine patients with metastatic breast cancer were treated with methyl-GAG at an initial starting dose of 500 mg/m2 iv weekly and then escalated by 50 mg/m2/week to tolerance. There were two partial responders among the 26 evaluable patients. Gastrointestinal and cutaneous reactions were the limiting toxic effects of methyl-GAG. Myelosuppression was mild and infrequent.
29例转移性乳腺癌患者接受了甲基甘氨酸铝治疗，初始静脉注射剂量为500mg/m²，每周一次，然后以50mg/m²/周的剂量递增至耐受剂量。在26例可评估的患者中有2例部分缓解。胃肠道和皮肤反应是甲基甘氨酸铝的剂量限制性毒性作用。骨髓抑制轻微且不常见。
