Schuyler M R, Bondarevsky E, Schwartz H J, Schmitt D
J Allergy Clin Immunol. 1981 Jul;68(1):72-8. doi: 10.1016/0091-6749(81)90126-3.
Corticosteroids, well known to increase susceptibility to infection, are often administered to atopic patients. Atopy may be associated with lymphocyte abnormalities and increased susceptibility to infections caused by intracellular organisms. We sought to determine whether atopic and nonatopic subjects respond in a similar manner to corticosteroids administered both systemically and locally. We compared the response of peripheral blood leukocytes of 15 atopic asthmatics and 10 nonatopic control subjects to prednisone or beclomethasone dipropionate. We determined leukocyte number, total eosinophil count, T-cell number, complement receptor lymphocyte number, and concanavalin A (Con A)- and phytohemagglutinin (PHA)-induced lymphocyte proliferation before and 5 hr after administration of 20 mg of prednisone orally or 336 micrograms of beclomethasone dipropionate by aerosol inhalation. Baseline values of the groups differed. The atopic asthmatic group had higher total eosinophil count, lower percent lymphocyte count, and slightly lower Con A- and PHA (high concentration)-induced lymphocyte proliferation. T-cell and complement receptor lymphocyte number were equivalent in both groups. Prednisone caused a profound eosinopenia, monocytopenia, T lymphopenia, depression of mitogen-induced lymphocyte proliferation, and increase in leukocyte number and complement receptor lymphocyte percent. Beclomethasone dipropionate was associated with little or no change in these parameters. We conclude that atopic asthma is not associated with a defect in corticosteroid-sensitive leukocyte populations and that beclomethasone dipropionate aerosol, as opposed to prednisone, does not alter peripheral blood mononuclear cell populations.
众所周知，皮质类固醇会增加感染易感性，但仍常被用于特应性患者。特应性可能与淋巴细胞异常以及细胞内病原体引起的感染易感性增加有关。我们试图确定特应性和非特应性受试者对全身和局部使用皮质类固醇的反应是否相似。我们比较了15名特应性哮喘患者和10名非特应性对照受试者的外周血白细胞对泼尼松或二丙酸倍氯米松的反应。我们在口服20 mg泼尼松或雾化吸入336 μg二丙酸倍氯米松之前和之后5小时，测定白细胞数量、嗜酸性粒细胞总数、T细胞数量、补体受体淋巴细胞数量，以及刀豆蛋白A（Con A）和植物血凝素（PHA）诱导的淋巴细胞增殖。两组的基线值有所不同。特应性哮喘组的嗜酸性粒细胞总数较高，淋巴细胞百分比较低，Con A和PHA（高浓度）诱导的淋巴细胞增殖略低。两组的T细胞和补体受体淋巴细胞数量相当。泼尼松导致严重的嗜酸性粒细胞减少、单核细胞减少、T淋巴细胞减少、丝裂原诱导的淋巴细胞增殖受抑制，以及白细胞数量和补体受体淋巴细胞百分比增加。二丙酸倍氯米松与这些参数的变化很小或没有变化有关。我们得出结论，特应性哮喘与皮质类固醇敏感的白细胞群体缺陷无关，并且与泼尼松不同，二丙酸倍氯米松气雾剂不会改变外周血单核细胞群体。
