Jokelainen M, Tiilikainen A, Lapinleimu K
Tissue Antigens. 1977 Oct;10(4):259-66. doi: 10.1111/j.1399-0039.1977.tb00755.x.
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive disease of the central nervous system. Its possible association with poliomyelitis was studied by measuring neutralizing antibodies against polio virus types 1, 2 and 3 in the sera and cerebrospinal fluids of 11 ALS-patients, but antibody titers did not markedly differ from those of the controls. The HLA antigens of 12 ALS patients were also determined, in order to reveal any possible genetically-determined susceptibility to the disease. Possible association of ALS with HLA-Bw40 was noted. In addition, the Bw40 antigen seemed to be associated with milder progression of the disease. The lymphocytes of the ALS patients seemed defective in their capacity to stimulate allogenic lymphocytes, possibly due to a relative decrease of B cells in the peripheral blood. Joint efforts of study groups of neuroepidemiology, immunology and genetics should be mobilized to reveal the true nature of these findings.
肌萎缩侧索硬化症（ALS）是一种致命的中枢神经系统进行性疾病。通过检测11例ALS患者血清和脑脊液中针对1、2、3型脊髓灰质炎病毒的中和抗体，研究了其与脊髓灰质炎的可能关联，但抗体滴度与对照组无明显差异。还测定了12例ALS患者的HLA抗原，以揭示对该疾病任何可能的遗传易感性。注意到ALS与HLA - Bw40可能存在关联。此外，Bw40抗原似乎与疾病进展较缓有关。ALS患者的淋巴细胞刺激同种异体淋巴细胞的能力似乎存在缺陷，这可能是由于外周血中B细胞相对减少所致。应调动神经流行病学、免疫学和遗传学研究小组的共同努力，以揭示这些发现的真实性质。
