Kott E, Livni E, Zamir R, Kuritzky A
Neurology. 1979 Jul;29(7):1040-4. doi: 10.1212/wnl.29.7.1040.
Cell-mediated immunity to poliovirus was demonstrated in 21 of 33 patients suffering from amyotrophic lateral sclerosis (ALS), whereas no response to poliovirus was found in patients suffering from other neurologic disorders or in healthy controls. Three of the severe bulbar cases produced a migration inhibition factor (MIF) in the presence of poliovirus, although skin tests to common antigens were negative. An increased incidence (46 percent) of HLA-A3 was found in patients with amytrophic lateral sclerosis. Nine of the 13 patients with HLA-A3 antigen also had a positive index of MIF to poliovirus. These findings suggest a strong linkage between HLA-A3 and poliovirus in the pathogenesis of amyotrophic lateral sclerosis.
在33例肌萎缩侧索硬化症（ALS）患者中，有21例表现出针对脊髓灰质炎病毒的细胞介导免疫，而患有其他神经系统疾病的患者或健康对照对脊髓灰质炎病毒无反应。3例严重延髓型病例在接触脊髓灰质炎病毒时产生了迁移抑制因子（MIF），尽管对常见抗原的皮肤试验呈阴性。在肌萎缩侧索硬化症患者中发现HLA - A3的发生率增加（46%）。13例具有HLA - A3抗原的患者中有9例对脊髓灰质炎病毒的MIF指数也呈阳性。这些发现表明，在肌萎缩侧索硬化症的发病机制中，HLA - A3与脊髓灰质炎病毒之间存在密切联系。
