Woo E, Nightingale S, Dick D J, Walls T J, French J M, Bates D
J Neurol Neurosurg Psychiatry. 1986 Apr;49(4):435-7. doi: 10.1136/jnnp.49.4.435.
Histocompatibility antigen (HLA A, B and DR) serotyping was performed on 65 patients with motor neuron disease in the northern region of England and compared to a large control population from the Newcastle upon Tyne area. Thirty two patients had amyotrophic lateral sclerosis, 17 had progressive bulbar palsy and 16 had progressive muscular atrophy. Ten patients had a more slowly progressive course. No significant HLA associations were observed in the motor neuron disease patients. Subdivision of the patients by the clinical course of their disease did not reveal any significant associations. Forty six motor neuron disease patients from the Newcastle upon Tyne area had a reduced frequency of HLA DR4 compared to the local control population. The relevance of histocompatibility antigens to the pathogenesis of motor neuron disease is discussed.
对英格兰北部65例运动神经元病患者进行了组织相容性抗原（HLA A、B和DR）血清分型，并与泰恩河畔纽卡斯尔地区的大量对照人群进行了比较。32例患者患有肌萎缩侧索硬化症，17例患有进行性延髓麻痹，16例患有进行性肌肉萎缩。10例患者病程进展较慢。在运动神经元病患者中未观察到显著的HLA相关性。根据疾病临床病程对患者进行细分未发现任何显著相关性。与当地对照人群相比，泰恩河畔纽卡斯尔地区的46例运动神经元病患者HLA DR4频率降低。讨论了组织相容性抗原与运动神经元病发病机制的相关性。
