Brandt de Oliveira R, Voltarelli J C, Meneghelli U G
Parasite Immunol. 1981 Summer;3(2):165-9. doi: 10.1111/j.1365-3024.1981.tb00395.x.
The association of severe strongyloidiasis and hypogammaglobulinaemia in one patient is described. Severe strongyloidiasis was observed twice (March 1971 and June 1974), and the Strongyloides stercoralis infestation probably lasted for at least 58 months (from March 1971 to December 1975), in spite of successive thiabendazole courses of treatment. Immunological studies performed disclosed severe, steady hypogammaglobulinaemia but no abnormality in cell-mediated immunity. The respiratory infections also seen during the follow-up were ascribable more to humoral immunity impairment than to cell-mediated immunity impairment. This is the first report of the association of hypogammaglobulinaemia and severe strongyloidiasis, and it suggests that humoral immunity plays a relevant role in the human defences against S. stercoralis infestation.
本文描述了一名患者严重类圆线虫病与低丙种球蛋白血症的关联。尽管连续使用噻苯达唑进行治疗，但严重类圆线虫病仍出现了两次（1971年3月和1974年6月），粪类圆线虫感染可能至少持续了58个月（从1971年3月至1975年12月）。进行的免疫学研究显示存在严重、持续的低丙种球蛋白血症，但细胞介导免疫无异常。随访期间出现的呼吸道感染更多归因于体液免疫受损而非细胞介导免疫受损。这是低丙种球蛋白血症与严重类圆线虫病关联的首例报告，表明体液免疫在人体抵御粪类圆线虫感染中发挥了相关作用。
