Hall K Y, Bergman K, Walford R L
Tissue Antigens. 1981 Jan;17(1):104-10. doi: 10.1111/j.1399-0039.1981.tb00673.x.
Current evidence suggests that a correlation exists between the capacity to perform excision repair of UV-induced DNA damage and maximum lifespan in different species. Preliminary evidence has also indicated differences of DNA repair capacities in lymphocytes of several strains of mice congenic at the H-2 locus. It is known that the H-2 system influences maximum lifespan potential in mice. In the present studies excision repair of UV-induced DNA damage, but not gamma-induced damage, was found to correlate the mean survival in the adult inbred mouse strains NZB and CBA, using PHA stimulated splenic lymphocytes. Furthermore, in (NZB X CBA)F2 hybrid with adult progeny the level of DNA repair of UV-induced damage corresponded to the H-2 allele (H-2d/2d from NZB or H-2b/2b from CBA) inherited from the parental strain. These studies suggest the possibility of a tricornered relationship between the main histocompatibility complex, one form of DNA repair, and lifespan within the species.
目前的证据表明，不同物种中紫外线诱导的DNA损伤切除修复能力与最大寿命之间存在相关性。初步证据还表明，在H-2位点同源的几株小鼠的淋巴细胞中，DNA修复能力存在差异。已知H-2系统影响小鼠的最大寿命潜力。在本研究中，使用PHA刺激的脾淋巴细胞，发现紫外线诱导的DNA损伤的切除修复与成年近交小鼠品系NZB和CBA的平均生存期相关，而γ诱导的损伤则不然。此外，在具有成年后代的（NZB×CBA）F2杂种中，紫外线诱导损伤的DNA修复水平与从亲本品系遗传的H-2等位基因（来自NZB的H-2d/2d或来自CBA的H-2b/2b）相对应。这些研究表明，主要组织相容性复合体、一种DNA修复形式与物种内寿命之间可能存在三角关系。
