Walford R L, Bergmann K
Tissue Antigens. 1979 Oct;14(4):336-42. doi: 10.1111/j.1399-0039.1979.tb00858.x.
In sets of mice congenic at H-2 and upon two backgrounds, and selected according to known differences in strain-specific lifespans, DNA repair efficiency in spleen cells was compared by two techniques: excision repair capacity following UV-irradiation, and bleomycin sensitivity. Significant differences between certain congenic partner sets were noted with both techniques, suggesting that the main histocompatibility complex influences DNA repair capacity.
在具有H-2基因且处于两种背景下的同基因小鼠组中,根据品系特异性寿命的已知差异进行选择,通过两种技术比较脾细胞中的DNA修复效率:紫外线照射后的切除修复能力和博来霉素敏感性。两种技术均发现某些同基因配对组之间存在显著差异,这表明主要组织相容性复合体影响DNA修复能力。