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主要组织相容性复合体相关基因对小鼠淋巴细胞中脱氧核糖核酸切除修复能力及博来霉素敏感性的影响。

Influence of genes associated with the main histocompatibility complex on deoxyribonucleic acid excision repair capacity and bleomycin sensitivity in mouse lymphocytes.

作者信息

Walford R L, Bergmann K

出版信息

Tissue Antigens. 1979 Oct;14(4):336-42. doi: 10.1111/j.1399-0039.1979.tb00858.x.

DOI:10.1111/j.1399-0039.1979.tb00858.x
PMID:94705
Abstract

In sets of mice congenic at H-2 and upon two backgrounds, and selected according to known differences in strain-specific lifespans, DNA repair efficiency in spleen cells was compared by two techniques: excision repair capacity following UV-irradiation, and bleomycin sensitivity. Significant differences between certain congenic partner sets were noted with both techniques, suggesting that the main histocompatibility complex influences DNA repair capacity.

摘要

在具有H-2基因且处于两种背景下的同基因小鼠组中,根据品系特异性寿命的已知差异进行选择,通过两种技术比较脾细胞中的DNA修复效率:紫外线照射后的切除修复能力和博来霉素敏感性。两种技术均发现某些同基因配对组之间存在显著差异,这表明主要组织相容性复合体影响DNA修复能力。

相似文献

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Influence of genes associated with the main histocompatibility complex on deoxyribonucleic acid excision repair capacity and bleomycin sensitivity in mouse lymphocytes.主要组织相容性复合体相关基因对小鼠淋巴细胞中脱氧核糖核酸切除修复能力及博来霉素敏感性的影响。
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引用本文的文献

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Immunoregulation in senescence: increased inducibility of antigen-specific suppressor T cells and loss of cell sensitivity to immunosuppression in aging mice.衰老过程中的免疫调节:衰老小鼠体内抗原特异性抑制性T细胞的诱导能力增强以及细胞对免疫抑制的敏感性丧失。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3803-7. doi: 10.1073/pnas.79.12.3803.