Klimas R A, Thompson W H, Calisher C H, Clark G G, Grimstad P R, Bishop D H
Am J Epidemiol. 1981 Jul;114(1):112-31. doi: 10.1093/oxfordjournals.aje.a113158.
The tripartite ribonucleic acid (RNA) genomes of 23 alternate isolates of La Crosse virus have been analyzed by the procedure of oligonucleotide fingerprinting. By comparison with the fingerprints of the three viral RNA species (large, medium and small) of prototype La Crosse virus, the viruses have been categorized in terms of the degree of their RNA sequence relatedness. The A type La Crosse viruses, which have been recovered from Wisconsin, Minnesota, Indiana and Ohio, have viral RNA sequences that are closely related to those of prototype La Crosse virus. The B type La Crosse viruses, which have been recovered from Minnesota, Wisconsin and Illinois, have RNA sequences which, although related, are easily distinguished from those of type A viruses. A La Crosse virus isolate obtained from Rochester, Minnesota, appears to be an intertypic type A/B recombinant, it has a small size RNA segment like those of the B type La Crosse virus isolates, but medium- and large-sized RNA species like those of the A type La Crosse virus isolates. The C type La Crosse viruses have viral RNA sequences that neither closely resemble the A or B type La Crosse viruses. They have been recovered from eastern Ohio, New York State, Texas, Georgia and North Carolina.
已通过寡核苷酸指纹图谱法对23株交替分离的拉克罗斯病毒的三方核糖核酸（RNA）基因组进行了分析。通过与原型拉克罗斯病毒的三种病毒RNA种类（大、中、小）的指纹图谱进行比较，根据其RNA序列相关性程度对这些病毒进行了分类。从威斯康星州、明尼苏达州、印第安纳州和俄亥俄州分离出的A型拉克罗斯病毒，其病毒RNA序列与原型拉克罗斯病毒的序列密切相关。从明尼苏达州、威斯康星州和伊利诺伊州分离出的B型拉克罗斯病毒，其RNA序列虽然相关，但很容易与A型病毒的序列区分开来。从明尼苏达州罗切斯特市获得的一株拉克罗斯病毒分离株似乎是一种A/B型间型重组体，它有一个像B型拉克罗斯病毒分离株那样的小尺寸RNA片段，但有像A型拉克罗斯病毒分离株那样的中、大尺寸RNA种类。C型拉克罗斯病毒的病毒RNA序列既不太类似于A型也不太类似于B型拉克罗斯病毒。它们是从俄亥俄州东部、纽约州、得克萨斯州、佐治亚州和北卡罗来纳州分离出来的。
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