巴泰病毒和恩加里病毒：M基因片段重配及其与东非严重发热疾病暴发的关联
Batai and Ngari viruses: M segment reassortment and association with severe febrile disease outbreaks in East Africa.
作者信息
Briese Thomas, Bird Brian, Kapoor Vishal, Nichol Stuart T, Lipkin W Ian
机构信息
Jerome L. and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
出版信息
J Virol. 2006 Jun;80(11):5627-30. doi: 10.1128/JVI.02448-05.
Abstract
Ngari virus is an orthobunyavirus recently recognized as a reassortant between Bunyamwera virus and an as yet unidentified M segment donor. Analysis of M segment sequences of Batai and Ilesha viruses revealed 95% deduced amino acid identity between Batai virus and Ngari virus. These findings suggest Batai virus as the donor of Ngari virus M segment sequence. Analysis of Batai virus-related African isolates identified UgMP-6830, isolated from mosquitoes in Uganda, as an isolate of Batai virus. KV-141, isolated during a febrile disease outbreak in Sudan, was identified as another isolate of Ngari virus, emphasizing a role of this reassortant virus in severe human illness throughout East Africa.
摘要
恩加里病毒是一种正布尼亚病毒，最近被认为是布尼亚姆韦拉病毒与一个尚未确定的M基因节段供体之间的重组病毒。对巴泰病毒和伊莱沙病毒M基因节段序列的分析显示，巴泰病毒与恩加里病毒之间推导的氨基酸同一性为95%。这些发现表明巴泰病毒是恩加里病毒M基因节段序列的供体。对与巴泰病毒相关的非洲分离株的分析确定，从乌干达蚊子中分离出的UgMP-6830为巴泰病毒的一个分离株。在苏丹一次发热疾病暴发期间分离出的KV-141被确定为恩加里病毒的另一个分离株，这突出了这种重组病毒在东非严重人类疾病中的作用。
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