Kozarevic D, McGee D, Vojvodic N, Gordon T, Racic Z, Zukel W, Dawber T
Am J Epidemiol. 1981 Jul;114(1):21-8. doi: 10.1093/oxfordjournals.aje.a113170.
The relationship of level of baseline serum cholesterol to the seven-year incidence of death from all causes and from specific causes was examined in a cohort of 11,121 Yugoslav males aged 35--62 years at the time of their initial examination (1964--1965). Serum cholesterol was negatively related to mortality, i.e., those with a lower cholesterol experienced a higher mortality than those with a higher cholesterol. The negative relationship was significant (as assessed by logistic regression) and remained significant after adjusting for obesity, systolic blood pressure, cigarette smoking, age, history of intestinal parasitism, and socioeconomic status (as measured by years of education). The negative association of serum cholesterol and subsequent mortality appeared to be due to the relationship of cholesterol to deaths due to cancer and to deaths due to respiratory disease (tuberculosis and cor pulmonale). The cancer death-serum cholesterol relationship was not statistically significant but the respiratory disease death-serum cholesterol relationship was. Serum cholesterol, as expected, was positively related to the incidence of coronary heart disease death.
在一项对11121名年龄在35至62岁之间的南斯拉夫男性进行的队列研究中（初始检查时间为1964年至1965年），研究了基线血清胆固醇水平与全因死亡率及特定病因死亡率的七年发生率之间的关系。血清胆固醇与死亡率呈负相关，即胆固醇水平较低者的死亡率高于胆固醇水平较高者。这种负相关具有统计学意义（通过逻辑回归评估），在对肥胖、收缩压、吸烟、年龄、肠道寄生虫病史和社会经济地位（以受教育年限衡量）进行调整后，该负相关仍然显著。血清胆固醇与后续死亡率之间的负相关似乎是由于胆固醇与癌症死亡以及呼吸系统疾病（结核病和肺心病）死亡之间的关系所致。癌症死亡与血清胆固醇之间的关系无统计学意义，但呼吸系统疾病死亡与血清胆固醇之间的关系具有统计学意义。正如预期的那样，血清胆固醇与冠心病死亡发生率呈正相关。
