新型抗真菌药萘替芬的体外活性
In vitro activity of naftifine, a new antifungal agent.
作者信息
Georgopoulos A, Petranyi G, Mieth H, Drews J
出版信息
Antimicrob Agents Chemother. 1981 Mar;19(3):386-9. doi: 10.1128/AAC.19.3.386.
Abstract
Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory concentration [MIC] range 0.1 to 0.2 microgram/ml), aspergilli (6 strains; MIC range, 0.8 to 12.5 microgram/ml), Sporothrix schenckii (2 strains; MICs, 0.8 and 1.5 microgram/ml), and yeasts of the genus Candida (77 strains; MIC range, 1.5 to greater than 100 microgram/ml). Its degree of efficacy is unaffected by the organism density in the test medium, and it is primarily fungicidal against dermatophytes as well as yeasts. Its in vitro efficacy is pH dependent and rises with increasing pH values.
摘要
萘替芬对皮肤癣菌（38株；最低抑菌浓度[MIC]范围为0.1至0.2微克/毫升）、曲霉菌（6株；MIC范围为0.8至12.5微克/毫升）、申克孢子丝菌（2株；MIC分别为0.8和1.5微克/毫升）以及念珠菌属酵母菌（77株；MIC范围为1.5至大于100微克/毫升）呈现出有趣的体外活性谱。其疗效程度不受测试培养基中菌密度的影响，并且对皮肤癣菌和酵母菌主要起杀菌作用。其体外疗效取决于pH值，并且随pH值升高而增强。
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本文引用的文献
1
[Deep-freeze preservation of fungi in liquid nitrogen as a basis for standardized inocula].
Mykosen. 1978 Jan;21(1):19-23.
2
Antifungal agents.
Prog Drug Res. 1978;22:93-147. doi: 10.1007/978-3-0348-7102-0_3.
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